四川农业大学学报 ›› 1997, Vol. 15 ›› Issue (02): 263-269,295.doi: 10.16036/j.issn.1000-2650.1997.02.023

• 研究论文 • 上一篇    下一篇

鸭瘟鸭病毒性肝炎二联弱毒疫苗的研究Ⅵ.二联疫苗对雏鸭早期最佳免疫途径的研究

程安春, 汪铭书, 崔恒敏, 廖德惠, 陈孝跃   

  1. 四川农业大学动物科技学院, 雅安市 625014
  • 收稿日期:1996-02-21 出版日期:1997-06-30 发布日期:2017-03-07
  • 基金资助:
    四川省教委资助的重点科研课题

STUDY ON BIVALENT ATTENUATED VACCINES AGAINST DP AND DVH Ⅵ. THE STUDIES ON THE EARLY STAGE IMMUNIZATION OF THE VACCINE

Cheng Anchun, Wang Mingshu, Cui Hengmin et al   

  1. College of Animal Science and Technology, Sichuan Agricultural University/Yaan, Sichuan, China 625014
  • Received:1996-02-21 Online:1997-06-30 Published:2017-03-07

摘要: 本文报道鸭瘟鸭病毒性肝炎二联弱毒疫苗对雏鸭进行早期免疫的试验结果。试验采用不含鸭瘟和鸭病毒性肝炎母源抗体和含不同滴度母源抗体水平的1日龄的四川麻鸭雏鸭,用鸭瘟鸭病毒性肝炎二联弱毒疫苗经皮下注射、饮水、滴鼻和喷雾进行免疫,探索不同免疫途径对鸭瘟和鸭病毒性肝炎的免疫效果及免疫持续期,选出最佳免疫途径。试验结果表明:1.对于没有母源抗体的1日龄雏鸭,用鸭瘟鸭病毒性肝炎二联弱毒疫苗进行免疫的最佳途经是皮下注射和饮水免疫,其中皮下注射效果比饮水稍好:①到3日龄产生对鸭病毒性肝炎部分免疫力,4日龄产生坚强免疫力;②皮下注射到3日龄、饮水免疫到4日龄均产生对鸭瘟的坚强免疫力,保护期持续2个月以上。2.对有母源抗体的雏鸭进行免疫的最佳途经是饮水免疫:①到3-4日龄产生对鸭病毒性肝炎部分免疫力,5日龄产生坚强免疫力;②3-4日龄产生对鸭瘟部分免疫力,5日龄产生对鸭瘟的坚强免疫力,其免疫持续期2个月以上。

关键词: 鸭瘟鸭病毒性肝炎二联苗, 雏鸭, 早期免疫, 效果, 鸭病[49NA]

Abstract: In this paper the studies on the early stage immunization of the bivalent attenuated vaccines against Duck Plague(DP) and Duck Viral Hepatitis(DVH)is reported. Sichuan flaxen ducklings without maternal antibody and with maternal antibody were used in the experiment. The duckings have been immunized by different routes(Subcutaneous, in drinking water, nose dripping and spraying). The results indicated: 1. The best immunization routes on duckings without maternal antibody are subcutaneous and in drinking water(Subcutaneous injection is slightly better than that in drinking water), ①all 4-day old immunized ducklings immunized by subcutaneous injection and in drinking water could resist the challenge of 10-thousand LD 50 virulent DHV; ②all 4-day old immunized ducklings immunized by subcutaneous injection and in drinking water could resist the challenge of 10-thousand M. L. D. virulent DPV, and 2 months later, the protection rate was 100%. 2. The best immunization routes on duckings with maternal antibody is that in drinking water, ① all 5-day old immunized ducklings immunized by that in drinking water could resist the challenge of 10-thousand LD 50 virulent DHV; ② all 4-day old immunized ducklings immunized by subcutaneous injection and in drinking water could resist the challenge of 10-thousand M. L. D. virulent DPV, the immunity period lasted for at least 2 months.

Key words: THE BIVALENT ATTENUATED VACCINES AGAINST DP AND DVH, DUCKLINGS, EARLY STAGE IMMUNIZATION, EFFECT, DUCK DISEASE

中图分类号: 

  • S855.3