四川农业大学学报

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烟酸铜(Ⅱ)螯合物的固相合成、表征及抑菌活性

谢勇平   

  1. 福建农林大学
  • 收稿日期:2011-09-16 修回日期:2011-11-30 出版日期:2011-12-25 发布日期:2011-12-26
  • 通讯作者: 谢勇平

Solid Phase Synthesis,Characterization and Antibacterial Activity of Copper(Ⅱ) Nicotinate

XIE YONGPING   

  1. Fujian Agriculture and Forestry University
  • Received:2011-09-16 Revised:2011-11-30 Online:2011-12-25 Published:2011-12-26
  • Contact: XIE YONGPING

摘要:

在室温条件下通过固相反应合成了烟酸铜螯合物,考察了铜源、反应时间、原料配比对合成产物的影响。实验结果表明,最佳的合成工艺条件为:以醋酸铜为铜源,反应时间为3 小时,醋酸铜:烟酸(摩尔比)=1:2。采用摩尔电导、元素分析、红外光谱、紫外光谱、以及X-射线粉末衍射光谱对所合成的螯合物进行了表征。抑菌活性实验表明该螯合物对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌和铜绿假单胞菌具有一定的抑菌活性。

关键词: 烟酸, 铜螯合物, 固相合成, 表征, 抑菌活性

Abstract:

A copper (Ⅱ) complex with nicotinic acid was synthesized by the method of room temperature solid phase synthesis. The effects of copper source type, reaction time and materials ratios on the product were investigated. The experiment result showed the optimum synthetic conditions as follow: using copper acetate as copper source, reaction time 3 h, copper acetate: nicotinic acid=1:2(mol:mol). The complex was characterized by molar conductance , elemental analysis, infrared spectra, ultraviolet spectra and X-ray powder diffraction. Antibacterial test displayed that the complexes have a certain antibacterial activity against staphylococcus aureus,bacillus subtilis, escherichia coli and bacillus aeruginosus.

Key words: nicotinic acid, copper complex, solid phase synthesis, characterization, antibacterial activity