关键词: 动力学, 代谢, 高压, 甲苯, 砜

Abstract: This paper reports on the pharmacokinetics of albendazole and its main metabolites-sulfoxide and sulfone in serum of milking goat given albendazole as a powder at a does rate of 20mg/kg weight by high performance liquid chromatographic method (HPLC). YWG-80 was chosen as solid phase and the mobile phase consisted of hexane ethanol acetonitrile (360:50:0.26v/v/v). The wavelenght of UV detector was 292nm. Mebendazole was used as an internal standard. The major parameters were respectively T1/2k、Tmax、Cmax、AUC of sulfoxide and sulfone are: 10.98(hr)、20.48(hr)、12.01(hr)、20.72(hr)、5.11(μg/ml)、1.79(μg/ml); 173.18(μg/ml.hr)、106.56(μg/ml.hr).

Key words: DYNAMICS, METABOLISN, HIGH PRESSSURE, METHYLBENZENE, SULFONE