复方紫草温敏凝胶的制备与质量评价

doi:10.16036/j.issn.1000-2650.2021.06.012

四川农业大学学报 ›› 2021, Vol. 39 ›› Issue (6): 791-798.doi: 10.16036/j.issn.1000-2650.2021.06.012

复方紫草温敏凝胶的制备与质量评价

徐科, 吴赟杰, 李金洋, 赵君晰, 张泽瀚, 梁晓霞^*

四川农业大学动物医学院天然药物研究中心,成都 611130

收稿日期:2021-02-18 出版日期:2021-12-30 发布日期:2021-12-31
通讯作者: ^*梁晓霞,博士,教授,主要从事天然药物化学研究,E-mail：liangxiaoxia@sicau.edu.cn。
作者简介:徐科,本科生。
基金资助:
省级大学生创新训练计划项目（202010626091）

Preparation and Quality Evaluation of Warm Sensitive Gel for the Compound ‘Zicao’

XU Ke, WU Yunjie, LI Jinyang, ZHAO Junxi, ZHANG Zehan, LIANG Xiaoxia^*

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130,China

Received:2021-02-18 Online:2021-12-30 Published:2021-12-31

摘要/Abstract

摘要： 【目的】制备复方紫草温敏凝胶并对其进行质量评价。【方法】采用冷溶法,以泊洛沙姆为基质制备复方紫草温敏凝胶。将胶凝温度作为考察指标对所制凝胶进行处方优化。从凝胶的理化性质、微生物限度等方面对所制备的凝胶制剂进行质量评价。【结果】所得复方紫草温敏凝胶的最佳处方为：16%P407+2%P188+4%甘油+8%复方紫草药液,平均胶凝温度为32.8 ℃。【结论】所制备复方紫草温敏凝胶质量稳定、胶凝温度合适,可为各种创伤的愈合提供更好的新选择。

关键词: 紫草复方, 温敏凝胶, 质量评价, 冷溶法, 处方优化

Abstract: 【Objective】 To prepare and evaluate the warm sensitive gel of compound ‘Zicao’. 【Method】 The warm sensitive gel of compound ‘Zicao’ was prepared with Poloxamer by cold solution. Taking the gelation temperature as an index,the formulation of the gel was optimized. The quality of the prepared gel was evaluated according to physicochemical property, and the microbial limit. 【Result】 The best prescription of the warm sensitive gel was prepared by 16% P407, 2% P188, 4% glycerol and 8% compound ‘Zicao’ extraction. The average gelation temperature of 32.8 ℃ was obtained. 【Conclusion】 The compound ‘Zicao’ warm sensitive gel is stable in quality and suitable in gelation temperature,providing a better new choice for the healing of various wounds.

Key words: compound ‘Zicao’, warm sensitive gel, quality evaluation, cold solution, prescription op-timization

中图分类号:

徐科, 吴赟杰, 李金洋, 赵君晰, 张泽瀚, 梁晓霞. 复方紫草温敏凝胶的制备与质量评价[J]. 四川农业大学学报, 2021, 39(6): 791-798.

XU Ke, WU Yunjie, LI Jinyang, ZHAO Junxi, ZHANG Zehan, LIANG Xiaoxia. Preparation and Quality Evaluation of Warm Sensitive Gel for the Compound ‘Zicao’[J]. Journal of Sichuan Agricultural University, 2021, 39(6): 791-798.

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复方紫草温敏凝胶的制备与质量评价

Preparation and Quality Evaluation of Warm Sensitive Gel for the Compound ‘Zicao’

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