关键词: 三聚氰胺, 慢性肾功能衰竭, 血肌酐, 猫

Abstract: 【Objective】 To establish a cat model of chronic renal failure (CRF), which lay a foundation for studying the pathogenesis of CRF in cats and evaluating the therapeutic effect of cat CRF drugs. 【Method】 A 1:1 mixture of melamine and cyanuric acid was continuously fed to test group cats at 20, 10 and 5 mg/kg for 21 days (21 times), and then fed once by two days for 14 days (7 times). Collected the blood and urine on 0,22 and 36 d to measure physiological and biochemical indexes. According to internationally recog-nized cat chronic renal failure grading standards to determine whether the model is successfully esta-blished. Finally, the renal tissues of dead cats were dissected to make pathological sections, and the pathological changes were observed by HE staining. 【Result】① The cats in the test group showed clinical symptoms of renal failure such as polydipsia, polyuria, and marasmus, with increased serum creatinine and urea nitrogen, decreased red blood cell number and urine specific gravity, and urine protein production. ② The renal histopathological results showed that the tubular epithelial cells vacuolar dege-neration and necrosis, tubular epithelial cells were shed in the center of the tubular lumen to form tubular type of renal tubular epithelial cells, and the glomerular structure was incomplete. 【Conclusion】 A stable mild or moderate cat CRF model could be established by feeding a 1:1 mixture of melamine and cyanuric acid at low (5 mg/kg) and medium (10 mg/kg) doses for 21 days, and then feeding the mixture once/two days for 14 days.

Key words: melamine, chronic renal failure, serum creatinine, cat