关键词: 贝诺酯, 4-二甲氨基吡啶(DMAP), 二环己基碳二亚胺(DCC), 正交优化

Abstract: [Objective] In order to explore the method of 4 dimethylaminopyridine(DMAP) catalytic synthesis for benorilate. [Method] Used the advantagesof DMAP and N, N'-dicyclohexylcarbodiimide(DCC) synthesis esters, and identified the products by the HPLC and IR. [Results] Used the single factor experiment to discuss the effects of reaction temperature, reaction time, raw material ratio, catalyst dosage and the amount of dehydrating agent for the impact on target yield. And optimize process conditions by orthogonal test. Optimal condition is DMAP:Aspirin=5:100(%), the mole ratio of DCC and Aspirinis 0.8:1.1, reaction temperature 40℃, reaction time 5h, according to the results of orthogonal test 3 parallel tests were conducted. The average yield of parallel test was 51%. [Conclusion] The experiment results show that the final screening method compared with the general method of production, has some advantages like simple operation process, reaction temperature are easily satisfied both in experiment and production, and the reaction process is safety and easy to control. This method is a new process, to provide a theoretical basis for the production.

Key words: Benorilate, 4-dimethylaminopyridine-catalyze(DMAP), Dicyclohexylcarbodiimide(DCC), orthogonal test