四川农业大学学报 ›› 2002, Vol. 20 ›› Issue (02): 148-149.doi: 10.16036/j.issn.1000-2650.2002.02.021

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磺胺嘧啶(SD)在鸡体内药代动力学的研究

廖玉辉1, 杨少华2, 林居纯1   

  1. 1. 四川农业大学 动物科技学院, 四川 雅安 625014;
    2. 乐山沙湾畜牧局, 四川 乐山 614019
  • 收稿日期:2001-10-22 出版日期:2002-06-30 发布日期:2017-03-06

Studies on Pharmacotinetics of Sulfadiazine in Hens

LIAO Yu-hui1, YANG Shao-hua2, LIN Ju-chun1   

  1. 1. College of Animal Science and Technology, Sichuan Agricultural University, Yaan 625014, Sichuan, China;
    2. Shawan Animal Husbandry Bureau, Leshan 614019, Sichuan, China
  • Received:2001-10-22 Online:2002-06-30 Published:2017-03-06

摘要: 雅安本地母鸡8只,1次口服SD胶囊200mg/kg,血中药物浓度测定用经典的Annino测定法显色,分光光度计测定,测定波长为550nm。磺胺嘧啶(SD)在血中的浓度经一时过程符合一级吸收一室开放模型,主要的药代动力学参数为:半衰期为5.53h,峰时为5.86h,峰浓度为7.32mg/100mL,血液有效浓度维持时间为12.5h。

关键词: 药物代谢动力学, 磺胺嘧啶,

Abstract: Pharmacokinetics of sulfadiazine was studied in Yaan hens. A single oral dose(200 mg/kg of b.w.) of sulfadiazine was administered to hens. Blood samples were collected at 0, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 14, 16, 22, 28, and 34 h after dosing. The samples were analysed chemically(spectrophometric analysis) by the Annino method. The experimental data were in accordance with 1-compartment open model with first order absorption. The major phamacokinetics parameters of sulfadiazine were:T1/2=5.53 h, Cmax=7.32 mg/100 mL, Tmax=5.86 h, Tcp=12.5 h.

Key words: PHARMACOKINETICS, SULFADIAZINE(SD), HEN

中图分类号: 

  • S859.7