四川农业大学学报 ›› 2005, Vol. 23 ›› Issue (01): 99-103.doi: 10.16036/j.issn.1000-2650.2005.01.021

• 研究论文 • 上一篇    下一篇

左氧氟沙星在健康鸡体内的药动学研究

蒋智钢, 李英伦   

  1. 四川农业大学 动物科技学院, 四川 雅安 625014
  • 收稿日期:2004-11-01 出版日期:2005-03-31 发布日期:2017-04-21
  • 基金资助:
    四川省教育厅重点项目(02279)。

Pharmacokinetics of Levofloxacin in Chickens after Oral Administration

JIANG Zhi-gang, Li Ying-lun   

  1. College of Animal and Technology, Sichuan Agricultural University, Yaan 625014, Sichuan, China
  • Received:2004-11-01 Online:2005-03-31 Published:2017-04-21

摘要: 报道左氧氟沙星在健康鸡体内的药动学研究。36只健康鸡单剂量内服左氧氟沙星[10mg/(kg·b·w)],采用高效液相色谱法测定血药浓度,最低检测限0.001mg/L,并以3P97药动学程序进行分析,药-时数据符合一级吸收二室模型,主要动力学参数如下:T1/2Ka为(0.815±0.043) h,T1/2α为(1.267±0.029) h,T1/2β为(3.492±0.352) h,Tpeak为(1.624±0.073) h,Cmax为(1.715±0.106) mg/L,AUC为(9.470±0.690) mg/(L·h),Tcp (ther)为6.668h,C (τ=12)为(0.789±0.058) mg/L,R为1.103±0.028,D*(D=10)为(11.025±0.275) mg/(kg·b·w)。结果表明:左氧氟沙星在健康鸡吸收迅速,血药浓度较高,分布广泛,消除较为缓慢。

关键词: 左氧氟沙星, 药动学, 鸡, 高效液相色谱法

Abstract: Pharmacokinetic variables of Levofloxacin were studied in chickens. The drug was given to 36 healthy chickens at a dosage of 10 mg per kilogram of body weight orally. Plasma Levofloxacin concentrations are determined by using high performance liquid chromatography, with a limit of detection of 0.001 mg of Levofloxacin per liter of plasma. Plasma Levofloxacin pharmacokinetic variables are calculated by using a two-compartment model with 1st order absorption in chickens with 3P97 PK program, with absorption, distribution and elimination half-lives of (0.815±0.043) h, (1.267±0.029) h and (3.492±0.352) h (x±S) respectively in chickens. The maximal plasma concentration is (1.715±0.106) mg/L, peaking for (1.624±0.073) h after dosing the drug to chickens. Other parameters are as for follow:AUC (9.470±0.690) mg/(L·h), Tcp (ther) 6.668 h, C (τ=12) (0.789±0.058) mg/L,R (1.103±0.028),D* (D=10) (11.025±0.275) mg/(kg·b·w). Pharmacokinetic Stigmata of Levofloxacin in healthy chickens are quick-absorption, high-Levofloxacin-concentration-in-plasma, widespread-distribution and slow-elimination.

Key words: Levofloxacin, pharmacokinetics, chickens, high performance liquid chromatography

中图分类号: 

  • S859.79