四川农业大学学报 ›› 1994, Vol. 12 ›› Issue (02): 293-297.doi: 10.16036/j.issn.1000-2650.1994.02.025

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狂犬病(HEP/BHK21)活疫苗免疫期试验

郭万柱, 陈代荣, 冯炳芳, 余广海, 蒋文灿, 罗时南, 龙平金, 王印   

  1. 四川农业大学/动物科技学院, 雅安市 625014
  • 收稿日期:1993-08-30 出版日期:1994-06-30 发布日期:2017-04-22

DURATION-OF-IMMUNITY STUDY IN DOGS OF RABIES LIVE VACCINE (HEP/BHK21)

Guo Wanzhu, et al   

  1. Collgeg of Animal Science and Technology Sichuan Agricultural university, Yaan, Sichuan, China 625014
  • Received:1993-08-30 Online:1994-06-30 Published:2017-04-22

摘要: 应用效价为10-4.50MICLD50/0.03ml的狂犬病HEP/BHK21活毒疫苗免疫犬后,对免疫前和免疫后1、3、6、12、30个月血样进行了血清学评价和免疫原性分析。15只犬免疫1月后,血清抗体全部阳转,66%的犬在30个月后抗体仍维持在一个较高水平。免疫1年后90%以上的动物能够得到保护。统计表明,不同地区、不同性别、不同年龄的犬免疫反应无显著差异,但三月龄以下犬反应欠佳。

关键词: 狂犬病(47MA), HEP/BHK21活疫苗, 免疫期, 免疫测定(47KD), 抗体(47KD)

Abstract: A rabies live vaccine (HEP/BHK21) was tested in dogs to determine, its duration of immnnity and immunogenicity.Dogs were vaccinated intramuscularly with a field dose of vaccine which was 10-4.50mouse intercerebral median lethal doses per 0.03ml.Blood samples were collected for serologic evaluation and immunogenicity test before inoculation and at 1;3, 6, 12, 30 months after vaccination.15 dogs produced high titer antibodies against rabies virus at 1 month after vaccination 66% of degs had high antibody titer at 30 months post-vaccination.A result of serumneutralization showed that 85% of dogs could be protected at 1 year after vaccination.The resuets of the present study indicated there was no distinst different antibody response in dogs of different area, sex and age, except pups.

Key words: RABIES VIRUS, HEP/BHK21 LIVE VACCINE, IMMUNITY DURATION

中图分类号: 

  • S855.3