四川农业大学学报 ›› 2007, Vol. 25 ›› Issue (01): 103-105.doi: 10.16036/j.issn.1000-2650.2007.01.021

• 研究论文 • 上一篇    下一篇

中药复方提取液在鲫鱼体内的药物代谢动力学

田海军1, 郑曙明2, 杨治国1   

  1. 1. 信阳农业高等专科学校 水产系, 河南 信阳 464000;
    2. 西南大学 动物科学学院, 重庆 北碚 400716
  • 收稿日期:2005-09-27 出版日期:2007-03-31 发布日期:2017-03-03
  • 基金资助:
    信阳农业高等专科学校青年科研专项基金资助。

Pharmacokinetics of One Compound Chinese Herbal Medicine in Carassius auratus

TIAN Hai-jun1, ZHENG Shu-ming2, YANG Zhi-guo1   

  1. 1. Department of Fishery Science, Xinyang Agricultural College, Xinyang 464000, He'nan, China;
    2. College of Animal Science, Southwest Agriculture University, Beibei 400716, Chongqing, China
  • Received:2005-09-27 Online:2007-03-31 Published:2017-03-03

摘要: 采用寇氏法进行中药复方提取液的急性毒性试验和用药物累积法进行其在鲫鱼体内的药物动力学研究。结果表明复方提取液的24 h LC50=1.207 g/mL,48 h LC50=1.101 g/mL,安全剂量0.785 g/kg。表观药动学参数:零时药物浓度C0=1.4817 g/kg,一级消除速率常数Kel=0.1063 h-1,消除半衰期t1/2=6.0113 h,清除率CLb=0.5851(g·h)/kg,药-时曲线下面积AUC=13.9388(g·h)/kg,表观分布容积V=1.9262。说明该复方提取液在鲫鱼体内代谢较快,药物的生物利用度高,药物与血浆蛋白结合率低,主要分布在组织中。

关键词: 鲫鱼, 药物累积法, 中药复方, 药代动力学

Abstract: This paper the acute toxicity of one compound Chinese herbal medicine and the pharmacokinetics of this medicine in Carassius auratus by drug cumulative method.The results are 24 h LC50=1.207 g/m L, 48 h LC50=1.101 g/mL, safe dose:0.785 g/kg.The apparent pharmacokinetics parameters are C0=14.817 g/kg, Kel=0.1063 h-1, t1/2=6.0113 h, CLb=0.5851(g·h)/kg, AUC=13.9388(g·h)/kg, V=1.9262 which shows that the metabolism of this medicine in carassias auratus is fast, that the medicine can be utilized biologically and it is mostly distributed in tissue.

Key words: drug cumulative method, compound Chinese herbal, Carassius auratus, pharmacokinetics

中图分类号: 

  • S853.74