四川农业大学学报 ›› 1996, Vol. 14 ›› Issue (04): 609-612,636.doi: 10.16036/j.issn.1000-2650.1996.04.026

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环丙沙星在山羊体内药代动力学研究

李英伦   

  1. 四川农业大学动物科技学院, 雅安市 625014
  • 收稿日期:1995-12-18 出版日期:1996-12-31 发布日期:2017-03-07

PHARMACOKINETICS STUDIES OF CIPROFLOXACIN IN GOATS

Li Yinglun   

  1. College of Animal Science and Technology, Sichuan Agricultural University/Yaan, Sichuan, China 625014
  • Received:1995-12-18 Online:1996-12-31 Published:2017-03-07

摘要: 本文报道以高压液相色谱法为定量手段,研究了六头本地山羊一次肌肉注射环丙沙星(2.8mg/kg)后,血中环丙沙星的药代动力学规律。测定条件:shim pack CLC-ODS,150×6mm不锈钢柱;流动相:甲醇-乙腈-0.02mol/L磷酸二氢钾溶液(10:10:80V/V/V;内含0.3%四丁基氢氧化铵,pH2.8±0.2);紫外检测波长:277nm。吡哌酸作内标,主要药动学参数为:M=3.59±1.83(μg/mL);Ka=(4.01±1.13)/h;K=(0.55±0.31)/h;T(1/2)Ka=0.18±0.06(h);T(1/2)K=1.69±1.06(h);Tmax=0.61±0.16(h);Cmax=2.09±0.7(μg/mL);AUC=58.3±1.34[μg/(mL.h)];CL(B)=0.51±0.21[mL/(kg.h)];V=1.10±0.45(L/kg)。

关键词: 环丙沙星, 高压液相色谱, 山羊[49ME], 药物代谢动力学[47UA]

Abstract: This paper reports a method for determination of Ciprofloxacin in serum healthy goats aftrr a singl intramuscular dose at rater of 2.8 mg/kg body weigth by HPLC. It was chosen shim-pack-CLC ods as asolid phase and the mobil phase consisted of methanolacetonituile -0.02mol/L potassium dihydrogenphosphate(10:10:80 V/V/V pH=2.8±0.2) at a flow at 1.0 mL min, The wavelength of uv detector was 227 nm. Pipemidic acid was used and internal. The major parameters are:M=3.59±1.83 μg/mL; Ka=(4.01±1.13)/h; K=(0.55±0.31)/h;T(1/2)Ka=0.18±0.06h;T(1/2)K=1.69±1.06h;Tmiax=0.61±0.16h; Cmax=2.09±0.7 μg/mL; AUC=5.83±1.34 μg/(mL.h); CL(B)=0.51±0.12mL/(kg.h); V=1.10±0.45L/kg.

Key words: CIPROFLOXACIN, HPLC, GOATS, PHARMACOKINETICS

中图分类号: 

  • S859.7