四川农业大学学报 ›› 1987, Vol. 5 ›› Issue (04): 309-312.doi: 10.16036/j.issn.1000-2650.1987.04.008

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磺胺嘧啶在鹅体内代谢动力学的研究

柳仲华, 王天益, 张福华   

  1. 四川农业大学兽医学系
  • 收稿日期:1987-04-10 出版日期:1987-12-31 发布日期:2017-04-22

PHARMACOKINETICS OF SULFADIAZINE IN GEESE

Liu Zhonghua, et al   

  1. Sichuan Agricultural University, Ya'an, Sichuan, China
  • Received:1987-04-10 Online:1987-12-31 Published:2017-04-22

摘要: 四川白鹅10只,一次口服SD胶囊100mg/kg,血药浓度测定用Annino法显色,用分光光度计测定,波长为550nm.动力学参数:半衰期为5.44小时,峰时为2.5小时,峰值为8.38mg%,血液中有效浓度维持时间为6.54小5。

关键词: 药物动力学, 生物鉴定,

Abstract: Pharmacokinetics of sulfadiazine was studied in healthy fourth-month goslings. A single oral dose of 100/kg of the drug was administered. Blood samples were collected at 0, 0.5, 1, 2, 3, 4, 6, 8, 10, and 12 hours. The samples were analyzed chemically (spectrophotometric assay) by the Annino method. The data were in accordance with one-compartment open model with first order absorption. The main kinetic parameters of sulfadiazine were determined.

Key words: PHARMACOKINETICS, BIOASSAY, GOOSE