四川农业大学学报 ›› 1984, Vol. 2 ›› Issue (02): 157-162.doi: 10.16036/j.issn.1000-2650.1984.02.009

• • 上一篇    

三种长效磺胺药在水牛体内的代谢动力学

张福华, 夏珍, 柳仲华, 张心如, 周祖华, 付佑全   

  1. 四川农学院
  • 收稿日期:1984-03-23 出版日期:1984-06-30 发布日期:2017-04-21

PHARMACOKINETICS OF SULFADOXINE (SDM), SULFAMETHOXYDIAZINE (SMD), AND SULFAMONOMETHOXINE (SMM) IN BUFFALOES

Zhang Fuhua, Xia Zhen, Liu Zhonghua, Zhang Xinru, Zhou Zuhua, Fu Youguan   

  1. Sichan Agricultural College, Ya'an, Sichuan, China
  • Received:1984-03-23 Online:1984-06-30 Published:2017-04-21

摘要: 磺胺-5,6-二甲氧嘧啶(SDM')为人用的周效磺胺。在奶山羊体内的代谢动力学已进行了研究(1)。磺胺-5-甲氧嘧啶(SMD)和磺胺-6-甲氧嘧啶(SMM、DS-36)亦为人用长效磺胺。SMM在鸡体内的分布(2)、在牛、猪的血中浓度、血浆蛋白结合率如乙酰化率(3)、对马(4)和奶山羊(5)体内的代谢动力学已进行了研究。

Abstract: Pharmacokinetics of sulfadoxine, sulfamethoxydiazine, and sulfamonomethoxone for injections were studied in healthy adult buffaloes. A single dose(SDM' 70mg/kg, SMD 50mg/kg, SMM 70mg/kg and 100mg/kg) of drugs administered as an intravenous bolus,and blood samples were collected at precisely timed intervals. The samples were analyzed chemically (spectrophotometric assay)by the Annino method (SDM' and SMD) and the Eckert method (SMM). The pharacokintic models were in accordance with those specified. The main kinetic parameters of SDM', SMD, and SMM (Ⅳ 70mg/kg and Ⅳ 100mg/kg) were determined.

Key words: PHARMACOKINETICS, BUFFALO