四川农业大学学报 ›› 1983, Vol. 1 ›› Issue (01): 121-128.doi: 10.16036/j.issn.1000-2650.1983.01.017

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山羊同种部份移植的实验研究

王文仕, 方尚文, 周熙, 赵金全   

  1. 四川农学院牧医系
  • 出版日期:1983-03-31 发布日期:2017-03-11

EXPERIMENTAL STUDIES OF HOMOGENOUS PARTIAL BONE GRAFTING IN GOATS

Wang Wenshi, Fang Shangwen, Zhou Xi, Zhao Jinguan   

  1. Sichuan Agricultural College
  • Online:1983-03-31 Published:2017-03-11

摘要: 骨的保存和移植在国内、外曾有过许多报导和专著(1)(2)(3)(4)(5)(6)(7)(8)。R.B.Olds(5)指出:"同种骨移植在-20℃或-30℃冰冻3-4个月或-76℃至少冰冻21-25天,移植后得到好的效果"。并认为感染的和未感染的移植物,其吸收是相同的。Fred Langer(6)等认为同种移植骨可使动物产生细胞和体液免疫,但可通过低温冰冻来克服,并证明冰冻在-20℃、-70℃及-196℃的骨移植,其效果没有区别,且在临床病例中没有看到移植骨被吸收的任何病例。R,Bruce Heppenstall(7)谈到在美国各种骨库惯用-70℃保存。温代如把狗骨放在4℃冷冻五天后,再放入-30℃冰冻备用,移植后获得成功。
为了更好的将这一技术应用于兽医临床,用同种骨代替骨的缺损,使骨重建,以避免或减少由于自体骨移植带来的取骨、植骨的术后并发病。克服大的骨损伤和幼龄动物自体骨移植供骨有限的困难。加之当前对骨吸收问题还认识不一等因素,有必要进一步探索家畜同种部份骨移植的形态、生物和免疫学方面的相容性、耐受性和移植骨吸收与否的规律,以及移植骨保存和固定的有效方法。

Abstract: Nine goats with negative blood cross reactions were allocated in two groups.The four goats in the first group were used for fresh homogeneous partial bone grafting. The Second group consisted of a donor and the other four goats which were used for frozen homogeneons partial bone grafting after the bone materials had been prepared under -18℃ for ten days.The locations of transplantation were on the inoide of metacarpus or metarsus.The heaeing states were examined Clinically,histologically and radiographically at 0.5,1.0,2.0,and 4.0 mo.after the operation.Although all the tested goats had been healing well.The frozen materials gave faster and better results Than the fresh bone materials.After grafting with fresh bone materials immogenic reaction was Observed.